Journal article
Simira Smith, Sual Lopez, Anastassiya Kim, Justina Kasteri, E. Olumuyide, Kristian Punu, Columba de la Parra, M. Sauane
Cancers, 2023
Cancers, 2023
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DOI
PubMedCentral
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APA
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Smith, S., Lopez, S., Kim, A., Kasteri, J., Olumuyide, E., Punu, K., … Sauane, M. (2023). Interleukin 24: Signal Transduction Pathways. Cancers.
Chicago/Turabian
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Smith, Simira, Sual Lopez, Anastassiya Kim, Justina Kasteri, E. Olumuyide, Kristian Punu, Columba de la Parra, and M. Sauane. “Interleukin 24: Signal Transduction Pathways.” Cancers (2023).
MLA
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Smith, Simira, et al. “Interleukin 24: Signal Transduction Pathways.” Cancers, 2023.
BibTeX Click to copy
@article{simira2023a,
title = {Interleukin 24: Signal Transduction Pathways},
year = {2023},
journal = {Cancers},
author = {Smith, Simira and Lopez, Sual and Kim, Anastassiya and Kasteri, Justina and Olumuyide, E. and Punu, Kristian and de la Parra, Columba and Sauane, M.}
}
Abstract
Simple Summary Interleukin 24 is a pleiotropic immunomodulatory cytokine. Numerous studies have shown that enhancing or inhibiting the expression of Interleukin 24 has a beneficial effect in animal models and clinical trials in different pathologies. We and others have already demonstrated the therapeutic utility of Interleukin 24 as an anticancer therapy and in autoimmune diseases and inflammation. Successful drug targeting will require a deeper understanding of the downstream signaling pathways. In this review, we discuss the signaling pathway triggered by Interleukin 24. Abstract Interleukin 24 is a member of the IL-10 family with crucial roles in antitumor, wound healing responses, host defense, immune regulation, and inflammation. Interleukin 24 is produced by both immune and nonimmune cells. Its canonical pathway relies on recognition and interaction with specific Interleukin 20 receptors in the plasma membrane and subsequent cytoplasmic Janus protein tyrosine kinases (JAK)/signal transducer and activator of the transcription (STAT) activation. The identification of noncanonical JAK/STAT-independent signaling pathways downstream of IL-24 relies on the interaction of IL-24 with protein kinase R in the cytosol, respiratory chain proteins in the inner mitochondrial membrane, and chaperones such as Sigma 1 Receptor in the endoplasmic reticulum. Numerous studies have shown that enhancing or inhibiting the expression of Interleukin 24 has a therapeutic effect in animal models and clinical trials in different pathologies. Successful drug targeting will require a deeper understanding of the downstream signaling pathways. In this review, we discuss the signaling pathway triggered by IL-24.
