The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra

Frontiers in Bioscience , vol. 29(3), 2024

Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.

A. Alard, Olga Katsara, Tiffany J. Rios-Fuller, C. Parra, U. Ozerdem, Amanda W Ernlund, R. Schneider

Cell Reports, 2023

Abstract 3704: The essential role of an alternate mRNA translation initiation in the regulation of breast cancer cell metabolism

Hanna Rosenstock, E. Mitaishvili, Columba de la Parra

Cancer Research, 2023

Interleukin 24: Signal Transduction Pathways

Simira Smith, Sual Lopez, Anastassiya Kim, Justina Kasteri, E. Olumuyide, Kristian Punu, Columba de la Parra, M. Sauane

Cancers, 2023

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Viviana Volta, S. Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda W Ernlund, Sophie Dornbaum, R. Schneider

Nature Communications, 2021

Abstract IA13: An mTOR/eIF4E-independent translation mechanism promotes breast cancer metastasis

C. Parra, Amanda W Ernlund, A. Alard, K. Ruggles, B. Ueberheide, Olga Katsara, R. Schneider

2020

Abstract A26: mTOR inhibition promotes differentiation of human regulatory T cells via privileged mRNA translation

Viviana Volta, Amanda W Ernlund, Abhilash Gadi, Amanda Valeta-Magara, C. Parra, Preeyam S. Patel, R. Schneider

2020

Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation

Ailed M Cruz-Collazo, C. Parra, R. Schneider, S. Dharmawardhane

Molecular and Cellular Biology / Genetics, 2019

Abstract A222: Exploiting mTORC1-independent protein synthesis in Tregs to boost antitumor immune response

Viviana Volta, Amanda W Ernlund, C. Parra, Abilash Gadi, Amanda Valeta-Magara, R. Schneider

Regulating T-cells and Their Response to Cancer, 2019

A widespread alternate form of cap-dependent mRNA translation initiation

Columba de la Parra, Amanda W Ernlund, A. Alard, K. Ruggles, B. Ueberheide, R. Schneider

Nature Communications, 2018

Translation initiation factors and their relevance in cancer.

Columba de la Parra, Beth A Walters, Phillip A Geter, R. Schneider

Current Opinion in Genetics and Development, 2018

Protein Synthesis Regulation by Soy Isoflavones Metabolite Equol in Metastatic Breast Cancer Cells

Ailed M Cruz-Collazo, C. Parra, R. Schneider, Suranganie Marie Dharmawardhane

2017

Abstract 4481: Translation initiation factor DAP5 plays an essential role in translational control of breast cancer metastasis

C. Parra, A. Alard, Amanda W Ernlund, R. Schneider

2017

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

Columba de la Parra, L. Castillo‐Pichardo, Ailed M Cruz-Collazo, L. Cubano, R. Redis, G. Calin, S. Dharmawardhane

Nutrition and Cancer, 2016

Downregulation of miR‐155 Contributes to The Anti‐proliferative Effects of The Soy Isoflavone Genistein in Estrogen Receptor Negative Breast Cancer

Columba de la Parra, Ailed M Cruz-Collazo, L. Castillo‐Pichardo, L. Cubano, R. Redis, G. Calin, S. Dharmawardhane

2015

Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G*

Columba de la Parra, Luis D Borrero-Garcia, Ailed M Cruz-Collazo, R. Schneider, S. Dharmawardhane

Journal of Biological Chemistry, 2015

BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion.

M. Cekanova, R. Fernando, N. Siriwardhana, Mugdha G Sukhthankar, Columba de la Parra, Jirayus Woraratphoka, Christine Malone, A. Ström, S. Baek, P. Wade, A. Saxton, R. Donnell, R. Pestell, S. Dharmawardhane, J. Wimalasena

Experimental Cell Research, 2015

Equol increases cancer potential via c-Myc upregulation 1 Equol , an isoflavone metabolite , regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF 4 G

C. Parra, Luis D Borrero-Garcia, Ailed M Cruz-Collazo, R. Schneider, S. Dharmawardhane

2014

Abstract A057: Therapeutic potential of genistein via targeting the microRNA miR-155 in breast cancer

C. Parra, L. Castillo‐Pichardo, L. Cubano, G. Calin, S. Dharmawardhane

2013

Increased protein synthesis of IRES containing mRNAs, that induce cell survival and proliferation, by the daidzein metabolite equol may contribute to breast cancer malignancy.

C. Parra, S. Dharmawardhane

2013

Abstract A155: The Rac and PAK inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model.

L. Castillo‐Pichardo, Tessa Humphries-Bickley, E. Hernández, C. Parra, L. Cubano, C. Vlaar, Surangani F. Dharmawardhane Flanagan

2013

Abstract 1988: Increased expression of eukaryotic protein synthesis initiation factor eIF4G by the daidzein metabolite equol may contribute to breast cancer malignancy

C. Parra, Elisa Otero-Franqui, S. Dharmawardhane

2012

Effect of processing on the phytochemical profiles and antioxidant activity of corn for production of masa, tortillas, and tortilla chips.

C. de la Parra, S. S. Saldívar, R. Liu

Journal of Agricultural and Food Chemistry, 2007

Effect of DHA Containing Oils and Powders on Baking Performance and Quality of White Pan Bread

S. Serna-Saldívar, R. Zorrilla, C. Parra, G. Stagnitti, R. Abril

Plant foods for human nutrition, 2006

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra

Frontiers in Bioscience , vol. 29(3), 2024

Abstract 3704: The essential role of an alternate mRNA translation initiation in the regulation of breast cancer cell metabolism

Hanna Rosenstock, E. Mitaishvili, Columba de la Parra

Cancer Research, 2023

Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.

A. Alard, Olga Katsara, Tiffany J. Rios-Fuller, C. Parra, U. Ozerdem, Amanda W Ernlund, R. Schneider

Cell Reports, 2023

Interleukin 24: Signal Transduction Pathways

Simira Smith, Sual Lopez, Anastassiya Kim, Justina Kasteri, E. Olumuyide, Kristian Punu, Columba de la Parra, M. Sauane

Cancers, 2023

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

Viviana Volta, S. Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda W Ernlund, Sophie Dornbaum, R. Schneider

Nature Communications, 2021

Abstract A26: mTOR inhibition promotes differentiation of human regulatory T cells via privileged mRNA translation

Viviana Volta, Amanda W Ernlund, Abhilash Gadi, Amanda Valeta-Magara, C. Parra, Preeyam S. Patel, R. Schneider

2020

Abstract IA13: An mTOR/eIF4E-independent translation mechanism promotes breast cancer metastasis

C. Parra, Amanda W Ernlund, A. Alard, K. Ruggles, B. Ueberheide, Olga Katsara, R. Schneider

2020

Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation

Ailed M Cruz-Collazo, C. Parra, R. Schneider, S. Dharmawardhane

Molecular and Cellular Biology / Genetics, 2019

Abstract A222: Exploiting mTORC1-independent protein synthesis in Tregs to boost antitumor immune response

Viviana Volta, Amanda W Ernlund, C. Parra, Abilash Gadi, Amanda Valeta-Magara, R. Schneider

Regulating T-cells and Their Response to Cancer, 2019

A widespread alternate form of cap-dependent mRNA translation initiation

Columba de la Parra, Amanda W Ernlund, A. Alard, K. Ruggles, B. Ueberheide, R. Schneider

Nature Communications, 2018

Translation initiation factors and their relevance in cancer.

Columba de la Parra, Beth A Walters, Phillip A Geter, R. Schneider

Current Opinion in Genetics and Development, 2018

Abstract 4481: Translation initiation factor DAP5 plays an essential role in translational control of breast cancer metastasis

C. Parra, A. Alard, Amanda W Ernlund, R. Schneider

2017

Protein Synthesis Regulation by Soy Isoflavones Metabolite Equol in Metastatic Breast Cancer Cells

Ailed M Cruz-Collazo, C. Parra, R. Schneider, Suranganie Marie Dharmawardhane

2017

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

Columba de la Parra, L. Castillo‐Pichardo, Ailed M Cruz-Collazo, L. Cubano, R. Redis, G. Calin, S. Dharmawardhane

Nutrition and Cancer, 2016

BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion.

M. Cekanova, R. Fernando, N. Siriwardhana, Mugdha G Sukhthankar, Columba de la Parra, Jirayus Woraratphoka, Christine Malone, A. Ström, S. Baek, P. Wade, A. Saxton, R. Donnell, R. Pestell, S. Dharmawardhane, J. Wimalasena

Experimental Cell Research, 2015

Downregulation of miR‐155 Contributes to The Anti‐proliferative Effects of The Soy Isoflavone Genistein in Estrogen Receptor Negative Breast Cancer

Columba de la Parra, Ailed M Cruz-Collazo, L. Castillo‐Pichardo, L. Cubano, R. Redis, G. Calin, S. Dharmawardhane

2015

Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G*

Columba de la Parra, Luis D Borrero-Garcia, Ailed M Cruz-Collazo, R. Schneider, S. Dharmawardhane

Journal of Biological Chemistry, 2015

Equol increases cancer potential via c-Myc upregulation 1 Equol , an isoflavone metabolite , regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF 4 G

C. Parra, Luis D Borrero-Garcia, Ailed M Cruz-Collazo, R. Schneider, S. Dharmawardhane

2014

Abstract A057: Therapeutic potential of genistein via targeting the microRNA miR-155 in breast cancer

C. Parra, L. Castillo‐Pichardo, L. Cubano, G. Calin, S. Dharmawardhane

2013

Abstract A155: The Rac and PAK inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model.

L. Castillo‐Pichardo, Tessa Humphries-Bickley, E. Hernández, C. Parra, L. Cubano, C. Vlaar, Surangani F. Dharmawardhane Flanagan

2013

Increased protein synthesis of IRES containing mRNAs, that induce cell survival and proliferation, by the daidzein metabolite equol may contribute to breast cancer malignancy.

C. Parra, S. Dharmawardhane

2013

Abstract 1988: Increased expression of eukaryotic protein synthesis initiation factor eIF4G by the daidzein metabolite equol may contribute to breast cancer malignancy

C. Parra, Elisa Otero-Franqui, S. Dharmawardhane

2012

Effect of processing on the phytochemical profiles and antioxidant activity of corn for production of masa, tortillas, and tortilla chips.

C. de la Parra, S. S. Saldívar, R. Liu

Journal of Agricultural and Food Chemistry, 2007

Effect of DHA Containing Oils and Powders on Baking Performance and Quality of White Pan Bread

S. Serna-Saldívar, R. Zorrilla, C. Parra, G. Stagnitti, R. Abril

Plant foods for human nutrition, 2006